Cardiovascular: parasitic arteritis
Synonym(s): verminous arteritis
Introduction
- Cause: lesions in wall of major arteries attributable to migratingStrongylus vulgarislarvae Strongylus spp .
- Signs: lesions in cranial mesenteric artery implicated in some cases of colic Abdomen: pain - adult .
- Diagnosis: history and clinical signs.
- Treatment: depends upon presentation.
- Prognosis: depends upon severity of condition. Severity of colic induced ranges from mild, recurrent, to severe, rapidly fatal. Aneurysms may rupture and lead to sudden death.
Presenting signs
- A localized inflammatory response in the artery is the most common presentation → embolic occlusion of larger or smaller mesenteric arteries → focal ischemia of jejunum, colon or cecum → colic.
- Aorto-iliac thrombosis is a vague hind limb lameness seen in males which may involve migrating strongyles in its etiology Cardiovascular: aortoiliac thrombosis .
Acute presentation
- Occasionally see ruptured aneurysms of cranial mesenteric artery with catastrophic blood loss into the abdomen and profound anemia.
- Or bleeding may be limited after rupture (eg hematoma confined within mesentery) and no effect on mucous membranes.
- Aortic rupture due to aneurysm occurs most commonly between right coronary artery and brachiocephalic trunk where parasitic arteritis involved and leads to sudden death Aorta: rupture .
- Pulmonary artery/renal artery rupture occasionally.
Age predisposition
- More commonly seen in horses <6 years old.
Cost considerations
- May be fatal, or require abdominal surgery.
Special risks
- Care must be taken with anesthesia as horse compromised due to blood loss/shock.
Pathogenesis
Etiology
- MigratingStrongylus vulgarislarvae Strongylus spp .
Predisposing factors
General- Poor management - failure to implement adequate deworming program.
Pathophysiology
- Larval migration → arteries → localized inflammation → embolic occlusion → infarction → areas of devitalized intestine and subsequent colic.
- May → ballooning of artery (aneurysm) → rupture.
- Arteritis most commonly occurs at root of cranial mesenteric arteries, or occasionally the renal arteries.
- MigratingStrongylus vulgarislarve → damage to tunica intima of cranial mesenteric arteries/aorta → narrowing of lumen, or localized (often severe) arteritis with variable numbers of larvae.
- Changes in the vessel wall (especially exposure of collagen) encourage platelet adhesion → release reaction → platelet aggregation which along with fibrin → thrombus formation.
- Sites of arterial damage → turbulent blood flow → eddy currents → allow platelets to settle on endothelial surface.
- Colic commonly results due to embolic occluson of mesenteric arteries → focal ischemia of jejunum, colon or cecum.
Aneurysm formation
- Destruction/disruption to muscular layer → localized enlargement/ballooning (aneurysm) of arterial wall.
- Aneurysms may rupture → catastrophic blood loss and possibly sudden death, especially if aorta involved.
Timecourse
- Colic may be mild, intermittent and recurrent, or may be of rapid onset and progression.
Diagnosis
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Treatment
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Prevention
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Outcomes
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Poole A W (1993)Thrombosis in the horse - the role of platelets in its pathogenesis and therapy. Equine Vet Educ 5 (2), 99-102 (A comparison between platelet function in the horse and other species related to anti-thrombotic therapy both present and future) VetMedResource.
- Drudge J H (1979) Clinical aspects of Strongylus vulgaris infection in the horse. Vet Clin North Am Pract 1 (2), 251-265 PubMed.