Introduction

Name

• Toltrazuril. 

Class of drug

• Triazinone antiprotozoal agent. 
• Coccidiocide. 

Description

Chemical name

• 1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfanyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione.   

Molecular formula

• C₁₈H₁₄F₃N₃O₄S. 

Molecular weight

• 425.38. 

Storage requirements

• No special precautions for storage. 

Uses

Indications

• Used orally to treat intestinal and hepatic coccidiosis Coccidiosis (Isospora ohioensis complex Isospora ohioensis, Isospora canis Isospora canis) in dogs. Effective against the replication of Isospora and also against the shedding of oocysts. Although treatment will reduce the spread of infection, it will not be effective against the clinical signs of infection in already infected animals. 
• Available in combination with the anthelmintic emodepside in the form of an oral suspension for use when there are mixed parasitic infections caused by roundworms and coccidia.  
• Toltrazuril has been used for treating the oocyst shedding stage of toxoplasmosis in cats.

Administration

Pharmacokinetics

Precautions

Adverse Reactions

Further Reading

Publications

Refereed Papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Procox SPC. https://www.ema.europa.eu/en/documents/product-information/procox-epar-product-information_en.pdf 
• Dubey J, Greene C (2006) Enteric coccidiosis. In: Greene C, ed. Infectious Diseases of the Dog and Cat, 3rd edn: Elsevier; pp 775-784.