ISSN 2398-2942      

Sildenafil

icanis
Contributor(s):

Gigi Davidson

Vetstream Ltd

Synonym(s): Sildenafil citrate, Viagra®, Revatio®, Aphrodil®


Introduction

Name

  • Sildenafil citrate.

Class of drug

  • Antihypertensive.
  • Peripheral vasodilator.
  • Erectile dysfunction agent in man.
  • Vasodilator.

Description

Chemical name

  • 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate

Molecular formula

  • C22H30N6O4S

Molecular weight

  • 474.58

Physical properties

  • Melting Point: 189-190°C.
  • Water Solubility: 3.5 mg/mL at 25°C.
  • pKa: 5.99.

Storage requirements

  • Store at controlled room temperature 20°C-25°C (68°F-77°F).
  • Excursions permitted to 15°C-30°C (59°F-86°F).

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Alpha-blockers or Amlodipine Amlodipine: synergistic hypotensive effects.
  • CYP3A4 Inhibitors: increase the effects of sildenafil:
  • Barbiturates: decrease sildenafil concentrations.
  • Rifampin Rifampicin: decreases sildenafil concentrations.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMedResource and PubMed.
  • Nakamura K et al (2011) Effects of sildenafil citrate on five dogs with Eisenmenger's syndrome. JSAP 52 (11), 595-598 PubMed.
  • Brown A J et al (2010) Clinical efficacy of sildenafil in treatment of pulmonary arterial hypertension in dogs. JVIM 24 (4), 850-854 PubMed.
  • Kellum H B & Stepien R L (2007) Sildenafil citrate therapy in 22 dogs with pulmonary hypertension. JVIM 21 (6), 1258-1264 PubMed
  • Bach J et al (2006) Retrospective evaluation of sildenafil citrate as a therapy for pulmonary hypertension in dogs. JVIM 20, 1132-1135 PubMed.
  • Walker D et al (1999) Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man. Xenobiotica 29 (3), 297-310 PubMed.

Other sources of information

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