ISSN 2398-2942      

Ibafloxacin

icanis
Contributor(s):

Linda Horspool


Introduction

Name

  • Ibafloxacin.

Class of drug

  • Fluoroquinolone antimicrobial.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Non-steroidal anti-inflammatory drugs

Use of NSAIDs in combination with ibafloxacin is contraindicated in epileptic dogs.

  • Concurrent administration of NSAIDs and fluoroquinolones potentiates CNS adverse effects in man.

Adsorbents and antacids

  • Absorbents and antacids Aluminum antacid containing cations (Mg, Al) may bind fluoroquinolones, interfering with their absorption from the GI tract.

Sucralfate and zinc salts

  • The absorption of fluoroquinolones may be inhibited by sucralfate Sucralfate and zinc salts.
    Separate doses of these drugs by at least 2 h.

Theophylline

  • Fluoroquinolones increase plasma theophylline Sucralfate concentrations.

Cimetidine

  • The clearance of fluoroquinolones may be reduced by cimetidine Cimetidine.

    Caution should be exercised before using cimetidine and fluoroquinolones concomitantly.

Nitrofurantoin

  • Antagonism may be observed with nitrofurantoin Nitrofurans.

 

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Horspool L J, van Laar P, van den Bos R et al (2006) Clinical efficacy of two ibafloxacin formulations in the treatment of canine pyoderma. Vet Rec 158 (7), 236-237 PubMed.
  • Horspool L J, van Laar P, van den Bos R et al (2004) Treatment of canine pyoderma with ibafloxacin and marbofloxacin--fluoroquinolones with different pharmacokinetic profiles. J Vet Pharmacol Ther 27 (3), 147-153 PubMed.
  • Coulet M, Van Borssum Waalkes M, Cox P et al (2002) In vitro and in vivo pharmacodynamic properties of the fluoroquinolone ibafloxacin. J Vet Pharmacol Ther 25 (6), 401-411 PubMed.
  • Coulet M, Van Borssum Waalkes M, Leeuwenkamp O R et al (2002) Pharmacokinetics of ibafloxacin following intravenous and oral adminstration to healthy Beagle dogs. J Vet Pharmacol Ther 25 (2), 89-97 PubMed.

Other sources of information

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