Introduction

Name

• Glipizide.

Class of drug

• Sulfonylurea.

Description

Storage requirements

• Keep cool.
• Avoid moisture.

Uses

Indications

• Management of type-II or non-insulin dependent diabetes mellitus (NIDDM) Diabetes mellitus where there is some residual insulin production.
• In these cases it may be effective alone or administered with insulin to reduce insulin requirements.
• Glipizide is ineffective when there is an absolute insulin deficiency (IDDM) or when insulin resistance is present.

Administration

Precautions

Interactions

with other drugs

• The effects of glipizide may be enhanced by ACE inhibitors, NSAIDs, chloramphenicol, potentiated sulfonamides and fluoroquinolones.
• Hypoglycemia may be increased by cimetidine administration.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Feldman E C, Nelson R W & Feldman M S (1997) Intensive 50-week evaluation of glipizide administration in 50 cats with previously untreated diabetes mellitus. JAVMA 210 (6), 772-777 PubMed.
• Nelson R W, Feldman E C, Ford S L et al (1993) Effect of an orally administered sulfonylurea, glipizide, for treatment of diabetes mellitus in cats. JAVMA 203 (6), 821-827 PubMed.

Other sources of information

• BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.