Introduction

Name

• Fluticasone propionate.

Class of drug

• Corticosteroid.

Description

Chemical name

• S-(fluoromethyl) 6alpha,9-difluoro-11beta,17-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carbothioate-17-propionate.

Molecular formula

• C25H31F3O5S.

Molecular weight

• 500.57.

Physical properties

• White powder insoluble in water.

Storage requirements

• Do not store >30°C (86°F).
• Do not refrigerate or freeze.
• Protect from frost and direct sunlight.

Uses

Indications

• Fluticasone is used specifically as an inhaled anti-inflammatory agent. The main indication of use in the dog would be in the management chronic bronchitis Chronic bronchitis or eosinophilic bronchitis Lung: pulmonary infiltration with eosinophilia.

Administration

Precautions

Interactions

with diagnostic tests

• Endogenous cortisol levels may be suppressed during treatment with fluticasone.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Cohn L A, DeClue A E, Reinero C R (2008) Endocrine and immunologic effects of inhaled fluticasone propionate in healthy dogs. J Vet Intern Med 22 (1), 37-43 PubMed.
• Bexfield N H, Foale R D, Davison L J et al (2006) Management of 13 cases of canine respiratory disease using inhaled corticosteroids. J Small Anim Pract 47 (7), 377-382 PubMed.
• Padrid P (2006) Use of inhaled medications to treat respiratory diseases in dogs and cats. J Am Anim Hosp Assoc 42 (2), 165-169 PubMed.