Introduction

Name

• Fluorouracil.

Class of drug

• Antineoplastic pyrimidine analogue.

Description

Chemical name

• 5-fluoro-2,4(1H,3H)-pyrimidinedione.

Molecular formula

• C4H3FN2O2.

Physical properties

• Solution.
• Cream.

Uses

Indications

• Basal cell tumor Chemotherapy: general principles.
• Squamous cell carcinoma Skin: squamous cell carcinoma (topically), intestinal carcinoma.
• Transitional carcinoma of the bladder Bladder: neoplasia - intracavitary therapy (tumors must be very superficial, a stage rarely seen in dogs).
• Mammary carcinoma Mammary gland: neoplasia.

Administration

Precautions

Interactions

with other drugs

Allopurinol Allopurinol

• Decreases hepatic activation.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Fischer D S, Knobf M T et al (2003) The Cancer Chemotherapy Handbook. 6th edn. Philadelphia, PA, Mosby. pp 128-130.
• BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.