Introduction

Name

• Florfenicol amine.

Class of drug

• Fluorinated synthetic analogue of the antibiotic thiamphenicol. 

Description

Chemical name

• (1R,2S)-2-amino-3-fluoro-1-(4-methylsulfonylphenyl)propan-1-ol.

Molecular formula

• C₁₂H₁₄Cl₂FNO₄S

Molecular weight

• 358.21

Physical properties

• Topical gel.

Storage requirements

• Refrigerator.

Uses

Indications

• Florfenicol-sensitive infections especially Staphylococcus pseudintermedius Staphylococcus pseudintermedius, efficacy against Pseudomonas spp Pseudomonas may be more limited.

Administration

Precautions

Interactions

With other drugs

• Interaction with other drugs has not been recognized.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Forster S L, Real T, Doucette K P et al (2018) A randomized placebo-controlled trial of the efficacy and safety of a terbinafine, florfenicol and betamethasone topical ear formulation in dogs for the treatment of bacterial and/or fungal otitis. BMC Vet Res 14 (1), 262 PubMed.
• King S B, Doucette K P, Seewald W et al (2018) A randomized, controlled, single-blinded multi-center evaluation of the efficacy and safety of a once weekly two dose otic gel containing florfenicol, terbinafine and betamethasone administered for the treatment of canine otitis externa. BMC Vet Res 14 (1), 307 PubMed.

Other sources of information

• Elanco: www.elanco.us/products-services/dogs/osurnia 
• Bayer: www.bayerdvm.com/products/claro-florfenicol-terbinafine-mometasone-furoate-otic-solution/