Introduction

Name

• Fentanyl transdermal solution 50 mg/mL (5% w/v).

Class of drug

• Analgesic.
• Opioid.
• Phenylpiperidene derivative.
• Controlled substance - Schedule II (UK), Class II opioid (US).

Description

Chemical name

• N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide

Molecular formula

• C22H28N2O

Molecular weight

• 336.47

Physical properties

• Product is clear, colorless solution.

Storage requirements

• Shelf life of product as packaged for sale: 3 years.
• Do not store or use near a naked flame (contains isopropyl alcohol).
• Store the broached vial with the adaptor in an upright position for up to 30 days.
• Store together with product information.
• Subject to the Schedule II controlled drugs storage requirements Controlled drugs: legal requirements for storage, prescription and supply.

Uses

Indications

• For the control of post-operative pain associated with major orthopedic and soft tissue surgery in dogs.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• To avoid anesthetic overdose in dogs, anesthetic agents should be administered until the desired effect is produced. Less anesthetic agent may be required than expected due to the anesthetic sparing effects of fentanyl.
• Use with caution in conjunction with morphine Morphine or other opioid type analgesics.
• Use with caution in conjunction with alpha2-adrenergic agonists (eg xylazine Xylazine , medetomidine Medetomidine , dexmedetomidine Dexmedetomidine ) due to potentially additive or synergistic effects.

with diagnostic tests

• None known.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Martinez S A, Wilson M G, Linton D D et al (2014) The safety and effectiveness of a long-acting transdermal fentanyl solution compared with oxymorphone for the control of postoperative pain in dogs: a randomized, multicentered clinical study. J Vet Pharmacol Ther 37 (4), 394-405 PubMed.
• Freise K J, Savides M C, Riggs K L et al (2012) Pharmacokinetics and dose selection of a novel, long-acting transdermal fentanyl solution in healthy laboratory Beagles. J Vet Pharmacol Ther 35 (Suppl 2), 21-26 PubMed.
• Freise K J, Newbound G C, Tudan C et al (2012) Pharmacokinetics and the effect of application site on a novel, long-acting transdermal fentanyl solution in healthy laboratory Beagles. J Vet Pharmacol Ther 35 (Suppl 2), 27-33 PubMed.
• Freise K J, Newbound G C, Tudan C et al (2012) Naloxone reversal of an overdose of a novel, long-acting transdermal fentanyl solution in laboratory Beagles. J Vet Pharmacol Ther 35 (Suppl 2), 45-51 PubMed.
• Freise K J, Linton D D, Newbound G C et al (2012) Population pharmacokinetics of transdermal fentanyl solution following a single dose administered prior to soft tissue and orthopedic surgery in dogs. J Vet Pharmacol Ther 35 (Suppl 2), 65-72 PubMed.
• Kukanich B, Clark T P (2012) The history and pharmacology of fentanyl: relevance to a novel, long-acting transdermal fentanyl solution newly approved for use in dogs. J Vet Pharmacol Ther 35 (Suppl 2), 3-19 PubMed.
• Linton D D, Wilson M G, Newbound G C et al (2012) The effectiveness of a long-acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs in a randomized, multicentered clinical study. J Vet Pharmacol Ther 35 (Suppl 2), 53-64 PubMed.
• Savides M C, Pohland R C, Wilkie D A et al (2012) The margin of safety of a single application of transdermal fentanyl solution when administered at multiples of the therapeutic dose to laboratory dogs. J Vet Pharmacol Ther 35 (Suppl 2), 35-43 PubMed.

Other sources of information

• European Medicine Agency. Summary of Product Characteristics Recuvyra.
• European Medicines Agency. European Public Assessment report Recuvyra.
• US Food and Drugs Administration. Freedom of Information Summary Recuvyra.

Organisation(s)

• American College of Veterinary Anesthesia and Analgesia
• Association of Veterinary Anaesthetists
• European College of Veterinary Anaesthesia and Analgesia
• European Veterinary Emergency and Critical Care Society
• Veterinary Anesthesia and Analgesia Support Group