ISSN 2398-2942      

Emodepside

icanis

Synonym(s): Profender (+ praziquantel), Procox (+toltrazuril)


Introduction

Name

  • Emodepside. 

Class of drug

  • Anthelmintic. 
  • Octadepsipeptide (depsipeptide). 

Description

Chemical name

  • N-methylated 24-membered cyclooctadepsipeptide, consisting of 4 alternating residues of N-methyl-L-leucine, 2 residues of D-lactate, and 2 residues of D-phenylacetate. 

Molecular formula

  • C60H90N6O14

Molecular weight

  • 1119.4

Physical properties

  • Used topically as a spot-on solution and orally as a suspension and as modified-release tablets. Suspension - shake well before use.

Uses

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Indications

  • Used in combination with praziquantel Praziquantel as modified-release tablets for dogs suffering from, or at risk from, mixed parasitic infections caused by roundworms and tapeworms. 
  • Used in combination with toltrazuril Toltrazuril as an oral suspension for dogs with mixed infections with roundworms and coccidia Coccidiosis.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Co-treatment with other drugs that are P-glycoprotein substrates/inhibitors (eg macrocyclic lactones, like ivermectin, milbemycin oxime, selamectin, moxidectin, erythromycin, prednisolone and cyclosporin) could give rise to pharmacokinetic drug interactions. The potential clinical consequences of such interactions have not been investigated.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Jimenez Castro P D, Mansour A, Charles S, Hostetler J, Settje T, Kulke D, Kaplan R M (2020) Efficacy evaluation of anthelmintic products against an infection with the canine hookworm (Ancylostoma caninum) isolate Worthy 4.1F3P in dogs. Int J Parasitol Drugs Drug Resist 22-27 Full Article.
  • Gaens D, Leithäuser C, Hamann M, Geyer J (2019) Adverse drug reactions after administration of emodepside/praziquantel (Profender®) in an MDR1-mutant australian shepherd dog: case report. Front Vet Sci 6, 296 PubMed Full Article

Organisation(s)

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