Doxepin
Synonym(s): Sinequan
Introduction
Name
- Doxepin.
Class of drug
- Tricyclic antidepressant.
Description
Chemical name
- 3-Dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine.
Molecular formula
- C19H21NO.
Physical properties
- Soluble in alcohol.
Storage requirements
- Light resistant container.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Gido C, Langguth P & Mutschler E (1994) Predictions of in vivo plasma concentrations from in vitro release kinetics: application to doxepin parenteral (i.m.) suspension in lipophilic vehicles in dogs. Pharm Res 11 (6), 800-808) PubMed.
- Brown T C & Leversha A (1979) Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitryptyline, and doxepin. Clin Toxicol 14 (3), 253-256 PubMed.
Other sources of information
- BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.
- Plumb Veterinary Drug handbook. 3rd edn. pp 261-262.