Introduction

Name

• Dinotefuran.

Class of drug

• Neonicotinoid insecticide (third generation).
• Antiparasitic products, insecticides and repellents, other ectoparasiticides for topical use, pyriproxyfen, combinations.

Description

Chemical name

• (EZ)-(RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine.
• N-methyl-N'-nitro-N''-[(tetrahydro-3-furanyl)methyl]guanidine.

Molecular formula

• C7H14N4O3

Molecular weight

• 202.21

Physical properties

• White crystalline solid.
• Licensed product: pale yellow solution (Vectra 3D).

Storage requirements

• Does not require any special storage conditions (room temperature).

Uses

Indications

• Kills adult fleas.
• Prevents infestation for 1 month.
• Can be used as part of a treatment strategy for flea allergic dermatitis Skin: flea bite hypersensitivity Skin: external parasite bite reaction.
• Two licensed product containing dinotefuran plus:
  • For dogs, the insect growth regulator pyriproxyfen Pyriproxifen and the acaricide permethrin Permethrin.
  • Pyriproxyfen extends the effects on developing stages of fleas to 3 months.
  • Permethrin extends the activity of the product in dogs to include ticks.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• Do not apply with other products at same site at same time.

with diagnostic tests

• None known.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Liénard E, Bouhsira E, Jacquiet P et al (2013) Efficacy of dinotefuran, permethrin and pyriproxyfen combination spot-on on dogs against Phlebotomus perniciosus and Ctenocephalides canis. Parasitol Res 112 (11), 3799-3805 PubMed.
• Bouhsira E, Lienard E, Jacquiet P et al (2012) Efficacy of permethrin, dinotefuran and pyriproxyfen on adult fleas, flea eggs collection, and flea egg development following transplantation of mature female fleas (Ctenocephalides felis felis) from cats to dogs. Vet Parasitol 190 (3-4), 541-546 PubMed.
• Franc M, Genchi C, Bouhsira E et al (2012) Efficacy of dinotefuran, permethrin and pyriproxyfen combination spot-on against Aedes aegypti mosquitoes on dogs. Vet Parasitol 189 (2-4), 333-337 PubMed.
• Horak I G, Fourie J J, Stanneck D (2012) Efficacy of slow-release collar formulations of imidacloprid/flumethrin and deltamethrin and of spot-on formulations of fipronil/(s)-- methoprene, dinotefuran/pyriproxyfen/permethrin and (s) -methoprene/amitraz/fipronil against Rhipicephalus sanguineus and Ctenocephalides felis felis on dogs. Parasit Vectors 5, 79 PubMed.
• Dryden M W, Payne P A, Vicki S et al (2011) Efficacy of dinotefuran-pyriproxyfen, dinotefuran-pyriproxyfen-permethrin and fipronil-(S)-methoprene topical spot-on formulations to control flea populations in naturally infested pets and private residences in Tampa, FL. Vet Parasitol 182 (2-4), 281-286 PubMed.
• Vo D T, Hsu W H, Abu-Basha E A et al (2010) Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J Vet Pharmacol Ther 33 (4), 315-322 PubMed.
• Coyne M J (2009) Efficacy of a topical ectoparasiticide containing dinotefuran, pyriproxyfen, and permethrin against Amblyomma americanum (Lone Star tick) and Amblyomma maculatum (Gulf Coast tick) on dogs. Vet Ther 10 (1-2), 17-23 PubMed.
• Murphy M, Ball C A, Gross S (2009) Comparative in vivo adulticidal activity of a topical dinotefuran versus an imidacloprid-based formulation against cat fleas (Ctenocephalides felis) on cats. Vet Ther 10 (1-2), 9-16 PubMed.
• Tomizawa M, Casida J E (2005) Neonicotinoid insecticide toxicology: mechanisms of selective action. Annu Rev Pharmacol Toxicol 45, 247-268 PubMed.

Other sources of information

• European Medicines Agency. Summary of Product Characteristics.Vectra Felis.
• European Medicines Agency. Summary of Product Characteristics.Vectra 3D.
• European Medicines Agency Public Assessment Report.Vectra Felis.
• European Medicines Agency Public Assessment Report.Vectra 3D.
• University of Hertfordshire. Agrochemicals database.Dinotefuran.

Organisation(s)

• CAPC www.capcvet.org
• ESCCAP www.esccap.org