Introduction

Class of drug

• Fluoroquinolone antimicrobial.

Uses

Indications

• Useful in management of urogenital (including prostatic Acute prostatitis ) and skin infections.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• Combination of NSAIDs and fluroquinolones in epileptic humans has been implicated in causing seizures.

• Drugs containing cations (Mg, Al) may bind to fluroquinolones preventing absorption from GI tract.

• May inhibit fluroquinolone absorption.
• Separate doses of these drugs by at least 2 hours.

• Fluroquinolones increase theophylline concentrations in plasma Theophylline.

• Blocks tubular secretion of fluroquinolones and may increase half-life and blood levels.

• May impair quinolone activity if used concurrently to treat urinary tract infections Nitrofurans

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.