Introduction

Name

• USAN.

Class of drug

• Inhalation anesthetic.

Description

Molecular formula

• Difluoromethyl 1-fluoro-2,2,2-trifluoroethyl ether.

Physical properties

• Blood/gas partition co-efficient: 0.42 (Halothane: 2.3, Isoflurane: 1.4).
• Oil/gas partition co-efficient: 18.7 (Halothane: 224, Isoflurane: 98).
• MAC: 6-8% (Halothane: 0.8, Isoflurane: 1.2).
• Highly volatile (saturated vapor pressure 700 mmHg).

Storage requirements

• Store in an airtight container.
• Protect from light.

Uses

Indications

• See: isoflurane Isoflurane

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• Enhances effect of competitive muscle relaxants.

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Clinical Anaesthetic Pharmacology, Editors: John W Dundee, R.S.J.Clarke, William McCaughey. Pub: Churchill Livingstone. 1991.
• Martindale - The Extra Pharmacopoeia The London Pharmaceutical Society. 31st Edition.
• Lumb and Jones. Veterinary Anaesthesia Williams and Williams 3rd Edition 1996.
• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 905214 44 7.