Introduction

Name

• Deracoxib.

Class of drug

• COX-2 inhibitor (although as with most COX-2 inhibitors, high doses can cause COX-1 inhibition).

Description

Chemical name

• 4-[3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole1-yl]benzenesulfonamide.

Molecular formula

• C17H14F3N3O3S

Storage requirements

• Keep put of reach of children.

Uses

Indications

• Treatment of chronic pain and lameness associated with osteoarthritis Arthritis: osteoarthritis in dogs.
• Relief of pain and inflammation associated with orthopedic surgery in dogs.
• Deracoxib is not licensed for administration to cats.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• Do not use together with non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids, medicines commonly used in the treatment of pain, inflammation and allergies. Dogs receiving ACE inhibitors and/or diuretics concurrently with deracoxib should be monitored carefully for signs of hypotension that will increase the risk of renal side effects.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Case J B, Fick J L, Rooney M B (2010) Proximal duodenal perforation in three dogs following deracoxib administration. JAAHA 46 (4), 255-258 PubMed.
• Gordon-Evans W J, Dunning D, Johnson A L et al (2010) Randomised controlled clinical trial for the use of deracoxib during intense rehabilitation exercises after tibial plateau levelling osteotomy. Vet Comp Ortho Traumatol 23 (5), 332-335 PubMed.
• Ryan W G, Carithers D, Moldave K et al (2010) Field comparison of canine NSAIDS firocoxib and deracoxib. J Appl Res Vet Med 8 (2), 114-123 VetMedResource.
• Roberts E S, Van Lare K A, Marable B R et al (2009) Safety and tolerability of 3- week and 6-month dosing of Deramaxx (deracoxib) chewable tablets in dogs. J Vet Pharmacol Therap 32 (4), 329-337 PubMed.
• Sennello K & Leib M S (2006) Effects of deracoxib or buffered aspirin on the gastric mucosa of healthy dogs. JVIM 20 (6), 1291-1296 PubMed.
• Lascelles B D, Blikslager A T, Fox S M et al (2005) Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002-2003). JAVMA 227 (7), 1112-1117 PubMed.

Other sources of information

• Deramaxx® (deracoxib): www.deramaxx.com/
• Deramaxx® packet insert: assets-us-01.kc-usercontent.com/0c9c95bf-d884-001c-8e80-5da5ada89c62/f7417aeb-8502-4936-b734-2b239fcdfbe2/Deramaxx_Insert.pdf
• Redorex packet insert: https://www.dechra-us.com/Files/Files/ProductDownloads/US/05IN-REX21002-1121-Rederox-PI-_-Insert_FINAL.pdf