Introduction

Name

• Cyproheptadine hydrochloride.

Class of drug

• Antihistamine, seratonin antagonist.

Description

Physical properties

• White powder - water soluble.

Storage requirements

• At room temperature.

Uses

Indications

• Symptomatic relief of allergic skin disease.
• Appetite stimulation in cats.
• Aid in management of feline asthma.
• Adjunctive therapy in treatment of hyperadrenocorticism Hyperadrenocorticism.

Administration

Precautions

Interactions

with other drugs

• Additive CNS effects with barbiturates.
• Monoamine oxidase inhibitors intensify anticholinergic effects.

with diagnostic tests

• Increases serum amylase concentrations inasocitation with thyrotropin releasing hormone.
• Decreases reaction to intradermal allergen testing.
  Discontinue for 7-10 days before performing test.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• García G, DeMora F, Ferrer L et al (1997) Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells. Am J Vet Res 58 (3), 293-297 PubMed.
• Peterson M E & Kintzer P P (1994) Medical treatment of pituitary-dependent hyperadrenocorticism in dogs. Semin Vet Med Surg - Sm Anim 9 (3), 127-131 PubMed.
• Scott D W, Miller W H Jr., Decker G A et al (1992) Failure of cyproheptadine hydrochloride as an antipruritic agent in allergic dogs: result of double-blinded, placebo-controlled study. Cornell Vet 82 (3), 247-251 VetMedResource.

Other sources of information

• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
• Plumb Veterinary Drug handbook 3rd edn. pp 190-192.