Introduction

Name

• Clodronate.

Class of drug

• Biphosphonate.

Description

Chemical name

• (Dichloromethylene)bisphosphonic acid;(dichloromethylene)diphosphonic acid; dichloromethanediphosphonic acid; CL2MDP; DMDP.

Molecular formula

• CH24CL2O6P2.

Uses

Indications

• Use to treat acute moderate to severe hypercalcemia when other therapies are ineffective.
• Use for long-term therapy of chronic hypercalcemia.
  There are very few reports of the use of this drug in dogs.

Administration

Precautions

Interactions

with other drugs

Antacids, calcium and iron salts

• Reduced absorption is seen if administered with antacids, calcium and iron salts.
  Administer 2 hours apart.

Aminogylosides

• Concurrent use may result in severe hypocalemia.

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.