Introduction

Name

• Amoxicillin/Clavulanate.

Class of drug

• Combination of amoxicillin Amoxicillin and beta-lactamase resistant penicillin antibiotic.

Description

Physical properties

• Powder.
• Tablets.
• Suspension.

Storage requirements

• In a cool and dry environment <25°C.
• All tablets are individually wrapped in foil, moisture-resistant packaging; do not remove until to be administered.
• Refrigerate oral suspension after reconstitution - discard if solution becomes dark or after 10 days.
• For IV suspension, after reconstitution, chemical and physical in-use stability has been demonstrated for 2-3 hours at 25°C, or 8 hours at 5°C. From a microbiological point of view, the reconstituted and diluted solution should be used immediately.

Uses

Indications

• This combination is active against gram-positive and gram-negative organisms, including penicillinase producing E. coli Escherichia coli and S. aureus Staphylococcus aureus.
• Pseudomonas Pseudomonas and Klebsiella are resistant.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

Probenecid

• Decreases the renal tubular secretion of penicillin antibiotics and thus prolongs their blood levels.

Aminoglycosides

• Do not mix in the same syringe as aminoglycosides.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Plumb’s Veterinary Drug Handbook. Plumb D C (2011) 7th Edition, Wiley-Blackwell, Ames, Iowa.
• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 905214 44 7.