Introduction

Name

• Cisapride.

Class of drug

• Prokinetic agent.

Description

Chemical name

• cis-4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidninyl]-2-methoxybenzamide;cis-4-amino-5-chloro-N-[1-[3-(p-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-o-anisamide.

Molecular formula

• C23H29CLFN3O4.

Storage requirements

• Store at room temperature.
• Keep out of light and keep dry.

Uses

Indications

• Management of:
  • Esophageal reflux Gastroduodenal reflux.
  • Gastric stasis.
  • Megacolon Megacolon: acquired.
  Cisapride has been withdrawn for use in humans in both the UK (July 2000) and USA. This decision follows reports of rare, but serious, ventricular arrhythmias (some fatal) suspected to be caused by the drug

Administration

Precautions

Interactions

with other drugs

• Opioid analgesics and antimuscarinics, eg atropine Atropine may antagonize cisapride's effects.
• Fatal arrhythmia may be seen in conjunction with:
  • Erythromycin, clarythromycin, troleandomycin.
  • Itraconazole, ketoconazole, fluconazole and miconazole.
• Increases bioavailability of cyclosporine.
• Increases absorption of aspirin, acetaminophen, diazepam, ethanol.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• LeGrange S N, Boothe D M, Herndon S et al (1997) Pharmacokinetics and suggested oral dosing regime of cisapride: a study in healthy cats. JAAHA 33 (6), 517-523 PubMed.

Other sources of information

• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.