Introduction

Name

• Chlorphenamine.

Class of drug

• H1 antihistamine.

Description

Chemical name

• Gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine.
• 2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]pyridine.

Molecular formula

• C16H19ClN2.

Physical properties

• Oily liquid.
• 1 g soluble in 4 ml water.

Storage requirements

• Injectable preparations should be stored in light-resistant containers

Uses

Indications

• Allergies.
• Anaphylactic reactions.

Administration

Precautions

Interactions

with other drugs

• CNS depressant drugs.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Paterson S (1995) Additive benefits of EFA's in dogs with atopic dermatitis after partial response to antihistamine therapy. JSAP 36 (9), 389-394 PubMed.
• Scott D W & Miller W H Jr. (1990) Nonsteroidal management of canine pruritus - chlorpheniramine and a fatty acid supplement (DVM Derm Caps) in combination, and the fatty acid supplement at twice the manufacturer's recommended dosage. Cornell Vet 80 (4), 381-387 PubMed.
• Misawa M, Takenouchi K, Sato M et al (1987) The effects of chlorpheniramine and antiallergic drugs on Ascaris suum antigen-induced active cutaneous anaphylaxis in dogs. Jpn J Pharmacol 44 (1), 101-104 PubMed.

Other sources of information

• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.