Introduction

Name

• Chlorothiazide.

Class of drug

• Thiazide diuretic.

Description

Chemical name

• 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide.

Molecular formula

• C7H6ClN3O4S2.

Physical properties

• Colorless.

Uses

Indications

• Management of systemic hypertension Hypertension.
• Management of nephrogenic diabetes insipidus Diabetes insipidus: nephrogenic.
• Management of congestive cardiac failure Heart: congestive heart failure.

Administration

Precautions

Interactions

with other drugs

• Increased risk of hypokalemia.

• Concurrent administration may lead to hyperglycemia and hypotension.

• Risk of hypercalcemia if thiazides are administered concurrently with calcium ot Vitamin D Vitamin D.

• May potentiate thiazide activity.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.