Introduction

Name

• Chlorambucil.

Class of drug

• Antineoplastic cytotoxic immunosuppressive alkylating agent.

Description

Chemical name

• 4-[bis(2-chloroethyl)amino]benzenebutanoic acid.
• 4-[p-[bis(2-chloroethyl)amino]phenyl]butryic acid.

Molecular formula

• C14H19Cl2NO2.

Physical properties

• 2 mg tablets.

Uses

Indications

• Lymphoproliferative Lymphoma , myeloproliferative, macroglobulinemia, and immune-mediated diseases Anemia: immune mediated hemolytic Arthritis: immune-mediated.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• Phenobarbitone Phenobarbital - increases cytotoxic effects of chlorambucil.
• Prednisolone Prednisolone - synergistic effect in management of lymphoid neoplasia.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Based on Small Animal Formulary. Ramsey, Ian (2016) 8th edn. Cheltenham: BSAVA.
• Fraizier D L & Hahn K A (1995) Commonly Used Drugs. In: Hahn K A & Richardson R C (eds) Cancer Chemotherapy A Veterinary Handbook. Philadelphia, PA. Williams & Wilkins. pp 90.