Introduction

Name

• Cefazolin Na.

Class of drug

• First generation cephalosporin antibiotic.

Uses

Indications

• Active against several gram-positive and gram-negative organisms, eg Pasteurellaspp,Staphyloccusspp Staphylococcus spp and Escherichia coli Escherichia coli.
• Resistant to bacterial beta-lactamase.
• Pseudomonasspp Pseudomonas and Proteusspp Proteus spp are resistant.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• The bactericidal activity of cephalosporins may be affected by the concomitant use of bacteriostatic agents (eg erythromycin Erythromycin , tetracycline Tetracycline ).

• For example frusemide Furosemide or amphotericin Amphotericin B.
• There may be an increased risk of nephrotoxicity; monitor renal function.

• Probenecid reduces the excretion of cephalosporins.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.