canis - Articles
Capromorelin
Synonym(s): ENTYCE®
Introduction
Name
- Capromorelin.
Class of drug
- Selective ghrelin receptor agonist.
Description
Chemical name
- 2-amino-N-[2-(3aR-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl)-1R-benzyloxymethyl-2-oxo-ethyl]-isobutyramide L-tartrate.
Molecular formula
- C28H35N5O4·C4H6O6
Molecular weight
- 655.70.
Physical properties
- Oral solution.
Storage requirements
- Store at or below 86°F (30°C).
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Rhodes L, Zollers B, Wofford J A et al (2017) Capomorelin: a ghrelin receptor agonist and novel therapy for stimulation of appetite in dogs. Vet Med Sci 4 (1), 3-16 PubMed.
- Zollers B, Rhodes L & Heinen E (2017) Capromorelin oral solution (ENTYCE®) increases food consumption and body weight when administered for 4 consecutive days to healthy adult Beagle dogs in a randomized, masked, placebo controlled study. BMC Vet Res 13 (1), 10 PubMed.
- Zollers B, Wofford J A, Heinen E et al (2016) A Prospective, Randomized, Masked, Placebo-Controlled Clinical Study of Capromorelin in Dogs with Reduced Appetite. JVIM 30 (6), 1851-1857 PubMed.
- Zollers B, Rhodes L, Smith R G (2016) Capromorelin increases food consumption, body weight, growth hormone, and sustained insulin-like growth factor 1 concentrations when administered to healthy adult Beagle dogs. J Vet Pharmacol Ther 40 (2), 140-147 PubMed.
- Zollers B, Huebner M, Armintrout G et al (2016) Evaluation of the safety in dogs of long-term, daily oral administration of capromorelin (ENTYCE®), a novel drug for stimulation of appetite. J Vet Pharmacol Ther 40 (3), 248-255 PubMed.