ISSN 2398-2942      

Benzylpenicillin

icanis

Synonym(s): Penicillin G


Introduction

Name

  • Penicillin G.

Class of drug

  • Penicillin antibiotic.

Description

Chemical name

  • [2S-(2-alpha,5-alpha,6-beta)]-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Molecular formula

  • C16H18N2O4S.

Physical properties

  • Sterile powder.
  • Sterile, aqueous suspension.

Storage requirements

  • Powder:
    • <25°C.
  • Suspension:
    • Between 2-8°C.
    • Do not store in freezer.
    • Protect from light.

Uses

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Indications

  • Used parenterally to treat serious infections caused by sensitive organisms, eg Streptococcus spp Streptococcus sppClostridium spp Clostridia sppBorrelia borgderferi Borrelia burgdorferi , some Staphylococcus spp and fusospirochetes.
  • When used for 'blind' therapy of undiagnosed serious infections penicillins may be given in conjunction with gentamicin Gentamicin and/or metronidazole Metronidazole.

Administration

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Precautions

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Interactions

with other drugs

Probenecid

  • Blocks the renal tubular excretion of penicillins, producing higher and more prolonged plasma concentrations.

Aminoglycosides, eg gentamicin

  • May inactivate penicillins when mixed together in parenteral solutions Gentamicin.

Streptomycin

  • Synergistic action. However, as their pharmacokinetics differ, the use of such compound preparations is generally thought to be unjustified Streptomycin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Plumb D C (2011) Plumb’s Veterinary Drug Handbook. 7th edn. Wiley-Blackwell, Ames, Iowa. 
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
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