Introduction

Name

• Benazepril.

Class of drug

• Angiotensin converting enzyme (ACE) inhibitor ACE inhibitor: overview.

Description

Chemical name

• Benazepril hydrochloride.
• [S-(R,R)]-3-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid.

Molecular formula

• C24H28N2O5.

Storage requirements

• Store in a dry place.
• Unused half tablets should be stored in the open blister spaces inside the cardboard box.

Uses

Indications

• Reduce afterload in cardiac insufficiency Heart: congestive heart failure.
• Treatment of hypertension Hypertension.
• May be of benefit in certain cases of renal insufficiency. Benazeprilat has significant hepatic metabolism, unlike enalaprilat, and may not require dose adjustment in renal failure.

Administration

Precautions

Interactions

with other drugs

• Concomitant use with potassium-sparing diuretics, eg spironolactone or potassium supplements may result in hyperkalemia.
• Can be administered in combination with digoxin, diuretics and anti-arrhythmic drugs.
• May be increased risk of nephrotoxicity when used with NSAIDs.
• Use with other anti-hypertensive drugs, eg calcium channel and beta blockers could cause hypotension.
• Anesthetics and sedative agents may potentiate hypotensive effects.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Ramsey I (2017) Small Animal Formulary. 9th edn.