Introduction

Name

• Amikacin.

Class of drug

• Aminoglycoside antibiotic.

Uses

Indications

• Gentamicin-resistant infections Gentamicin.
• Gram-negative infections.

Administration

Precautions

Interactions

with other drugs

• Other nephrotoxic, ototoxic or neurotoxic agents, eg amphotericin B, cisplatin, frusemide, methoxyflurane. Increase monitoring and adjust dosages when these drugs must be used with amikacin.
• Aminoglycosides may be inactivated by Beta-lactam antibiotics, eg penicillins, cephalosporins or heparin when mixed in vitro. This may present a problemin vivoin patients who have substantially diminished renal function.
• The effect of Non-depolarizing muscle relaxants, eg atracurium, pancuronium, tubocuramine, vecuronium may be enhanced by aminoglycosides.
• Synergism may occur when aminoglycosides are used with Penicillins or cephalosporins (Streptococcus faecalis) or ticarcillin Ticarcillin (Pseudomonas aeruginosa Pseudomonas aeruginosa ).

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK. ISBN: 0 905214 44 7.