Introduction

Name

• Aglepristone.

Class of drug

• Progesterone receptor antagonist.

Description

Chemical name

• (8S,11R,13S,14S,17R)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Molecular formula

• C29H37NO2

Molecular weight

• 431.60958

Physical properties

• Clear yellow oily solution.

Storage requirements

• Shelf life of 3 years.
• Once opened must be used within 28 days and discarded if discoloration occurs.
• As the available veterinary formulation contains no antibacterial preservative, swab the opening's membrane with suitable disinfectant each time before withdrawing the dose to be administered.
• Protect the bottle from light.

Uses

Indications

• Induction of abortion up to 45 days after unintended mating in bitches Mesalliance.

Administration

Precautions

Interactions

with other drugs

• Avoid use with ketoconazole Ketoconazole , itraconazole Itraconazole and erythromycin Erythromycin as interaction may occur.
• May reduce the effect of glucocorticoid treatment.

with diagnostic tests

• Hematological and biochemical changes (urea, creatinine, chloride, potassium, sodium, ALT, ALP, AST) reported in up to 5% of dogs following injection Blood biochemistry: overview.

Precautions for the personnel handling the product

• Women in childbearing age should avoid contact with the product or wear disposable plastic gloves when handling the product.
• Pregnant women should handle the product with extreme care.
• Care should be taken by the veterinary surgeon when administering the product and the person restraining the treated dog to avoid self-injection.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Agaoglu A R, Schäfer-Somi S, Kaya D et al (2011) The intravaginal application of misoprostol improves induction of abortion with aglepristone. Theriogenology 76 (1), 74-82 PubMed.
• Rigau T, Rodríguez-Gil J E, García F et al (2011) Partial foetal retention following aglepristone treatment in a bitch. Reprod Domest Anim 46 (4), 738-741 PubMed.
• Pettersson C H, Tidholm A (2009) Safety and efficacy of mid-term pregnancy termination using aglepristone in dogs. JSAP 50 (3), 120-123 PubMed.
• Schäfer-Somi S, Aksoy O A, Beceriklisoy H B et al (2007) Repeated induction of abortion in bitches and the effect on plasma concentrations of relaxin, progesterone and estradiol-17beta. Theriogenology 68 (6), 889-895 PubMed.
• Corrada Y, García P, de la Sota P E et al (2005) Decrease of body temperature after aglepristone treatment in bitches. Anim Reprod Sci 87 (3-4), 295-299 PubMed.
• Fieni F, Martal J, Marnet P G et al (2001) Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534). J Reprod Fertil Suppl 57, 243-248 PubMed.
• Galac S, Kooistra H S, Butinar J et al (2000) Termination of mid-gestation pregnancy in bitches with aglepristone, a progesterone receptor antagonist. Theriogenology 53 (4), 941-950 PubMed.
• Hubler M, Arnold S (2000) [Prevention of pregnancy in bitches with the progesterone antagonist aglepristone (alizone)]. Schweiz Arch Tierheilkd 142 (7), 381-386 PubMed.

Other sources of information

• BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn.