Introduction

Name

• Acepromazine maleate

Class of drug

• Phenothiazine.

Chemical name

• 1-[10-[3-(dimethylamino)propyl]-10 H-phenothiazin-2-yl]ethanone.
• 10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl ketone.

Molecular formula

• C19H22N2OS.C4H4O4.

Physical properties

• Pale yellow solution or tablets.

Storage requirements

• <25°C.
• Protect from light.

Uses

Indications

• Sedation Sedation sedative protocols.
• Pre-medication Anesthetic premedication: overview.
• Sedation for GIT contrast studies as minimal effect on transit time.
• Management of aortic thromboembolism in cats.

Administration

Precautions

Interactions

with other drugs

• Other central nervous system (CNS) depressants (barbiturates [Pentobarbital] , opioids, anesthetics) may cause additive CNS depression.
• Quinidine may cause additive cardiac depression.
• Anti-diarrheal mixtures , eg kaolin/pectin , bismuth subsalicylate, and antacids may decrease gastrointestinal (GI) absorption of oral phenothiazine.
• Propranolol : may increase blood levels of both drugs.
• Epinephrine : may lead to unopposed beta activity hence vasodilation and tachycardia because phenothiazines block alpha-adrenergic receptors.
• Phenytoin : metabolism may be decreased.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn.