ISSN 2398-2942      

Natriuretic peptides

icanis
Contributor(s):

Barrett Bulmer


Introduction

  • The natriuretic peptides (NP) are a group of structurally related but genetically distinct peptides that induce vasodilation and natriuresis.
  • NPs are released in response to physiological and pathological stimulation, including:
    • Exercise.
    • Hypoxia.
    • Ischemia.
    • Sepsis Shock: septic.
    • Increased cardiac wall stress.
    • Chamber dilatation/stretch.
  • Although atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been most extensively studied, C-type natriuretic peptide (CNP) and dendroaspis natriuretic peptide (DNP) have also been identified.

Pathophysiology

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Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)

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Elimination and measurement

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Use of NP assays

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Chetboul V, Tessier-Vetzel D, Escriou C et al (2004) Diagnostic potential of natriuretic peptides in the occult phase of golden retriever muscular dystrophy cardiomyopathy. J Vet Intern Med 18 (6), 845-850 PubMed.
  • Sisson D D (2004) Neuroendocrine evaluation of cardiac disease. Vet Clin North Am Small Anim Pract 34 (5), 1105-1126 PubMed.
  • Han B, Hasin Y (2003) Cardiovascular effects of natriuretic peptides and their interrelation with endothelin-1. Cardiovasc Drugs Ther 17 (1), 41-52 PubMed.
  • MacDonald K A, Kittleson M D, Munro C et al (2003) Brain natriuretic peptide concentration in dogs with heart disease and congestive heart failure. J Vet Intern Med 17 (2), 172-177 PubMed.
  • Tidholm A, Häggström J, Hansson K (2001) Effects of dilated cardiomyopathy on the renin-angiotensin-aldosterone system, atrial natriuretic peptide activity, and thyroid hormone concentrations in dogs. Am J Vet Res 62 (6), 961-967 PubMed.
  • Kitagawa H, Kitoh K, Inoue H et al (2000) Plasma renin activities, angiotensin II concentrations and cardiopulomary function values in dogs with severe heartworm disease. J Vet Med Sci 62 (4), 453-455 PubMed.
  • Häggström J, Hansson K, Kvart C et al (1997) Effects of naturally acquired decompensated mitral valve regurgitation on the renin-angiotensin-aldosterone system and atrial natriuretic peptide​ concentration in dogs. Am J Vet Res 58 (1), 77-82 PubMed.

Other sources of information

  • Oyama M A & Sisson D D (2006) Predictive value of natruiretic peptide and cardiac troponin-I testing in dogs with moderate to severe congenital subaortic stenosis. J Vet Intern Med 20 (3), 733.
  • Prosek R, Sisson D D, Oyama M A et al (2004) Use of plasma ANP, BNP, endothelin-1 and troponin-I levels in distinguishing between cardiac and non-cardiac causes of acute dyspnea in dogs. J Vet Intern Med 18 (3), 810-811.

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