Introduction

• The natriuretic peptides (NP) are a group of structurally related but genetically distinct peptides that induce vasodilation and natriuresis.
• NPs are released in response to physiological and pathological stimulation, including:
  • Exercise.
  • Hypoxia.
  • Ischemia.
  • Sepsis Shock: septic.
  • Increased cardiac wall stress.
  • Chamber dilatation/stretch.
• Although atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been most extensively studied, C-type natriuretic peptide (CNP) and dendroaspis natriuretic peptide (DNP) have also been identified.

Pathophysiology

Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)

Elimination and measurement

Use of NP assays

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Chetboul V, Tessier-Vetzel D, Escriou C et al (2004) Diagnostic potential of natriuretic peptides in the occult phase of golden retriever muscular dystrophy cardiomyopathy. J Vet Intern Med 18 (6), 845-850 PubMed.
• Sisson D D (2004) Neuroendocrine evaluation of cardiac disease. Vet Clin North Am Small Anim Pract 34 (5), 1105-1126 PubMed.
• Han B, Hasin Y (2003) Cardiovascular effects of natriuretic peptides and their interrelation with endothelin-1. Cardiovasc Drugs Ther 17 (1), 41-52 PubMed.
• MacDonald K A, Kittleson M D, Munro C et al (2003) Brain natriuretic peptide concentration in dogs with heart disease and congestive heart failure. J Vet Intern Med 17 (2), 172-177 PubMed.
• Tidholm A, Häggström J, Hansson K (2001) Effects of dilated cardiomyopathy on the renin-angiotensin-aldosterone system, atrial natriuretic peptide activity, and thyroid hormone concentrations in dogs. Am J Vet Res 62 (6), 961-967 PubMed.
• Kitagawa H, Kitoh K, Inoue H et al (2000) Plasma renin activities, angiotensin II concentrations and cardiopulomary function values in dogs with severe heartworm disease. J Vet Med Sci 62 (4), 453-455 PubMed.
• Häggström J, Hansson K, Kvart C et al (1997) Effects of naturally acquired decompensated mitral valve regurgitation on the renin-angiotensin-aldosterone system and atrial natriuretic peptide​ concentration in dogs. Am J Vet Res 58 (1), 77-82 PubMed.

Other sources of information

• Oyama M A & Sisson D D (2006) Predictive value of natruiretic peptide and cardiac troponin-I testing in dogs with moderate to severe congenital subaortic stenosis. J Vet Intern Med 20 (3), 733.
• Prosek R, Sisson D D, Oyama M A et al (2004) Use of plasma ANP, BNP, endothelin-1 and troponin-I levels in distinguishing between cardiac and non-cardiac causes of acute dyspnea in dogs. J Vet Intern Med 18 (3), 810-811.