Introduction

• The following chemotherapy protocols for mast cell tumors will be covered:
  • Protocol 1: Vinblastine/prednisolone protocol.
  • Protocol 2: Alternating vinblastine/cyclophosphamide + prednisolone protocol.
  • Protocol 3: Alternating vinblastine/lomustine + prednisolone protocol.
  • Protocol 4: CCNU + prednisolone.
  • Protocol 5: Tyrosine kinase inhibitors (TKI). 
  • Protocol 6: Chlorambucil + prednisolone. 

Protocols are not listed in order of preference or efficacy.Do not use without consulting specialist oncologist.Refer to chemotherapy safety administration Chemotherapy: safe handling.

Protocol 1

Protocol 2

Protocol 3

Protocol 4

Protocol 5

Protocol 6

Legal and safety precautions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Olsen J A, Thomson M, O'Connell K, Wyatt K (2018) Combination vinblastine, prednisolone and toceranib phosphate for treatment of grade II and III mast cell tumours in dogs. J Vet Med Sci 4 (3), 237-251 PubMed.
• Tjostheim S S, Stepien R L, Markovic L E, Stein T J (2016) Effects of Toceranib Phosphate on Systolic Blood Pressure and Proteinuria in Dogs. J Vet Intern Med 30(4), 951-957 PubMed. 
• Grant J, North S, Lanore D (2016) Clinical response of masitinib mesylate in the treatment of canine macroscopic mast cell tumours. JSAP 57(6), 283-290 PubMed.
• Smrkovski O A, Essick L, Rohrbach B W, Legendre A M (2015) Masitinib mesylate for metastatic and non‐resectable canine cutaneous mast cell tumours. Vet Comp Oncol 13(3), 314-321 PubMed.
• Carlsten K S, London C A, Haney S, Burnett R,  Avery A C, Thamm D H (2012) Multicenter Prospective Trial of Hypofractionated Radiation Treatment, Toceranib, and Prednisone for Measurable Canine Mast Cell Tumors. J Vet Intern Med 26(1), 135-141 PubMed.
• Hahn K A, Legendre A M, Shaw N G, Phillips B, Ogilvie G K et al (2010) Evaluation of 12- and 24-month survival rates after treatment withmasitinib in dogs with nonresectable mast cell tumors. Am J Vet Res 71 (11), 1354-1361 PubMed.
• London C A, Malpas P B, Wood-Follis S L, Boucher J F, Rusk A W et al (2009) Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or Distant) Mast Cell Tumor Following Surgical Excision. Clin Cancer Res 15 (11), 3856-3865 PubMed.
• Taylor F, Gear R, Hoather T et al (2009) Chlorambucil and prednisolone chemotherapy for dogs with inoperable mast cell tumors: 21 cases. JSAP 50 (6), 284-289 PubMed.
• Hahn K A, Oglivie G, Rusk T et al (2008) Masitinib Is Safe and Effective for the Treatment of Canine Mast Cell Tumors. JVIM 22(6), 1301-1309 PubMed.
• Camps-Palau M A, Leibman N F, Elmslie R et al (2007) Treatment of canine mast cell tumours with vinblastine, cyclophosphamide and prednisone: 35 cases (1997-2004). Vet Comp Oncol 5 (3), 156-167 PubMed.
• Thamm D H, Turek M M, Vail D M (2006) Outcome and prognostic factors following adjuvant prednisone/vinblastine chemotherapy for high-risk canine mast cell tumour: 61 cases. J Vet Med Sci 68 (6), 581-587 PubMed.
• Kristal O, Rassnick K M, Gliatto J M et al (2004) Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs. J Vet Intern Med 18 (1), 75-80 PubMed.
• Charney S C, Bergman P J, Hohenhaus A E et al (2003) Risk factors for sterile hemorrhagic cystitis in dogs with lymphoma receiving cyclophosphamide with or without concurrent administration of furosemide: 216 cases (1990-1996). J Am Vet Med Assoc 222 (10), 1388-1393 PubMed.
• Rassnick K M, Moore A S, Williams L E et al (1999) Treatment of canine mast cell tumors with CCNU (lomustine). J Vet Intern Med 13 (6), 601-605 PubMed.
• Thamm D H, Mauldin E A, Vail D M (1999) Prednisone and vinblastine chemotherapy for canine mast cell tumor - 41 cases (1992-1997). J Vet Intern Med 13 (5), 491-497 PubMed.