ISSN 2398-2969      

Skin: pemphigus erythematosus

icanis

Introduction

  • Rare benign focal form of pemphigus foliaceus Skin: pemphigus foliaceus , shares some features with discoid lupus erythematosus Skin: discoid lupus erythematosus.
  • Cause: varied, but usually unknown.
  • Signs: erythema, pustular dermatitis on face ( periocular, junction of nasal planum to haired skin, occasionally lip margins) and ears, nasal depigmentation.
  • Diagnosis: history, clinical signs, histopathology.
  • Treatment: immunosuppressive chemotherapy.
  • Prognosis: good.
    Print off the owner factsheet on Pemphigus to give to your client.

Pathogenesis

Pathophysiology

  • Same as P. vulgaris Skin: pemphigus vulgaris but with the lesions being less deep as the subcorneal epidermis is targeted rather than the stratum basale.
  • Depigmentation of lesions → sun aggravates → photodermatitis. (Not same mechanism as most photodermatitis cases/UV rays specifically exacerbates the original disease in this case.)

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Griffies J D, Mendelsohn C L, Rosenkrantz W S et al (2004) Topical 0.1% tacrolimus for the treatment of discoid lupus erythematosus and pemphigus erythematosus in dogs. J An Anim Hosp Assoc 40, 29-41 PubMed.
  • Werner A H (1999) Recognizing and treating discoid lupus erythematosus and pemphigus foliaceus in dogs. Vet Med 94, 955-966.
  • White S D, Rosychuk R A, Reinke S I et al (1992) Use of tetracycline and niacinamide for treatment of autoimmune skin disease in 31 dogs. JAVMA 200 (10), 1497-1500 PubMed.
  • Carloti D (1989) Autoimmune mediated skin disease. JSAP 30 (40), 223-227 VetMedResource.
  • Carlotti D (1989) Proceedings of 1987 symposium on skin disease at Lanwade Hall, Newmarket JSAP 30, 223-227.
  • Johnson B W & Campbell K L (1989) Dermatoses of the canine eyelid. Comp Cont Ed Pract Vet 11 (4), 385-394 VetMedResource.
  • Griffin C E (1987) Diagnosis and management of primary auto-immune skin diseases - a review. Seminars in Veterinary Medicine and Surgery (3), 173-185 PubMed.

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