Introduction

• Cause: rarely documented syndrome; may be caused by testicular neoplasia or may be idiopathic.
• Testicular neoplasia causes perianal gland and tail gland hyperplasia.
• Signs: idiopathic hyperandrogenism causes truncal alopecia and greasy scaling.
• Diagnosis: history, clinical signs, ultrasonography, hormone assay, response to castration.
• Treatment: castration.
• Prognosis: variable.

Pathogenesis

Etiology

• Elevated serum androgen due to:
  • Testicular neoplasia, especially interstitial cell tumors Testicle: neoplasia.
  • Idiopathic.

Pathophysiology

• Increased serum androgen → excess stimulation of perianal (hepatoid) tissue of circumanal and tail gland as well as sebaceous glands → glandular hyperactivity → hyperplasia and increased secretion.

Diagnosis

Treatment

Outcomes