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Sensory neuropathy: Border Collie
Introduction
- Cause: hereditary disease, autosomal recessive trait.
- Signs: knuckling of the feet, self-mutilation and progressive ataxia without paresis from 2 to 7 months of age.
- Diagnosis: DNA testing for sensory neuropathy.
- Treatment: none.
- Prognosis: grave with euthanasia usually required on welfare grounds before two years of age.
Presenting signs
- Knuckling of the feet.
- Pelvic limb ataxia Ataxia.
- Erosion of the foot pads.
- Urinary incontinence Urinary incontinence and regurgitation Regurgitation can occur in late stage of the disease.
Acute presentation
- None.
Age predisposition
- 2 to 7 months of age.
Breed/Species predisposition
- Border collie Border Collie.
Pathogenesis
Etiology
- Genetic disease.
- DNA mutation.
- Autosomal recessive mode of inheritance.
Pathophysiology
- Progressive axonopathy.
Timecourse
- Progressive deterioration over a year to 18 months.
Diagnosis
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Treatment
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Prevention
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Outcomes
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Harkin K R, Cash W C, Shelton G D (2005) Sensory and motor neuropathy in a Border Collie. J Am Vet Med Assoc 227 (8), 1263-1265 PubMed.
- Vermeersch K, Van Ham L, Braund K G et al (2005) Sensory neuropathy in two Border Collie puppies. J Small Anim Pract 46 (6), 295-299 PubMed.
- Wheeler S J (1987) Sensory neuropathy in a Border Collie puppy. J Small Anim Pract 28 (4), 281-289 VetMedResource.
Other sources of information
- For information on Genetic Testing Providers (labs) genetic tests, and tests by breed, visit International Partnership for Dogs (https://dogwellnet.com/).
- For a list of DNA tests available for certain breeds worldwide, visit Kennel Club Worldwide DNA tests: https://www.thekennelclub.org.uk/health/for-breeders/dna-testing-simple-inherited-disorders/worldwide-dna-tests/.