canis - Articles
Pure red cell aplasia
Introduction
- Selective failure of erythropoiesis (maturation arrest at early normoblast stage) but normal production of white blood cells and platelets.
- Insidious onset, non-regenerative anemia.
- Cause: potentially immune-mediated.
- Signs: weight loss.
- Diagnosis: bone marrow aspirate.
- Treatment: immunosuppressive therapy may, on occasion, be helpful.
- Prognosis: good to fair.
Presenting signs
- Exercise intolerance.
- Depression.
- Pica
- Anorexia.
- Weight loss.
Acute presentation
- Collapse, eg following exertion, due to anemia.
Pathogenesis
Etiology
- Idiopathic.
- Immune-mediated is possible.
- May be secondary to parvovirus infection - suggested but not proven.
Pathophysiology
- Immune-mediated destruction of red cell precursors → non-regenerative anemia Anemia: non-regenerative.
- Serum immunoglobulin G inhibitor → decreased erythroid colony precursors → insidious onset anemia → physiological compensation → relatively mild signs even if severe anemia.
Timecourse
- Gradual onset over weeks or months.
Diagnosis
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Treatment
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Prevention
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Outcomes
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