Introduction

• Active ingredient = cyclonite, also known as RDX, chemical names: hexahydro-1,3,5-trinitro-1,3,5-trizine, cyclotrimethylenetrinitramine.
• Signs: congested mucous membranes, fever, increased pulse, hyperventilation, hypersensitivity, mild convulsions.
• Diagnosis: history, clinical signs.
• Treatment: symptomatic.

Pathogenesis

Etiology

• Access to plastic explosives

Predisposing factors

• Seen mainly in explosive 'sniffer dogs'.

Pathophysiology

• → decreased food intake.

• Dose (experimental in rats) → affects limbic structures →central nervous system (CNS) signs/seizures.

Timecourse

• Signs 7 hours after (experimental) dosage.

Diagnosis

Treatment