Introduction

• Inflammatory disease causing necrosis.
• Breed specific (Maltese).
• Forebrain disease with usually acute onset.
• Cause: unknown.
• Signs: seizures and behavioral changes. Asymmetric clinical signs.
• Diagnosis: MR imaging most reliable antemortem diagnosis.
• Treatment: none.
• Variable progression. Fatal or requires euthanasia.

Pathogenesis

Predisposing factors

• None known.

Specific

• None known.

Pathophysiology

• Pathologic changes usually asymmetric in cerebral parenchyma and meninges.
• Non-suppurative infiltration of cells.

Timecourse

• Can be acute and progressive over days to weeks.
• Described as fatal due to progressive neurological compromise.
• Invariably necessitates euthanasia Euthanasia.

Diagnosis

Treatment

Outcomes