ISSN 2398-2969      

Necrotizing meningoencephalitis (Maltese)

icanis

Synonym(s): Non-suppurative CNS inflammatory disease


Introduction

  • Inflammatory disease causing necrosis.
  • Breed specific (Maltese).
  • Forebrain disease with usually acute onset.
  • Cause: unknown.
  • Signs: seizures and behavioral changes. Asymmetric clinical signs.
  • Diagnosis: MR imaging most reliable antemortem diagnosis.
  • Treatment: none.
  • Variable progression. Fatal or requires euthanasia.

Pathogenesis

Predisposing factors

General
  • None known.

Specific

  • None known.

Pathophysiology

  • Pathologic changes usually asymmetric in cerebral parenchyma and meninges.
  • Non-suppurative infiltration of cells.

Timecourse

  • Can be acute and progressive over days to weeks.
  • Described as fatal due to progressive neurological compromise.
  • Invariably necessitates euthanasia Euthanasia.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Fearnside S M, Kessell A E, Powe J R (2004) Cervical hyperaesthesia in a Maltese Terrier with necrotising meningoencephalitis. Aust Vet J 82 (9), 550-552 PubMed.
  • Thomas W B (1998) Inflammatory diseases of the central nervous system in dogs. Clin Tech Small Anim Pract 13 (3), 167-178 PubMed.
  • Stalis I H, Chadwick B, Dayrell-Hart B, Summers B A, Van Winkle T J (1995) Necrotizing meningoencephalitis of Maltese dogs. Vet Pathol 32 (3), 230-235 PubMed.

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