Introduction

• Described in the Clumber and Sussex Spaniel.
• Seen in puppies.
• Signs: exercise intolerance and collapse.
• Treatment: specific therapies are not available but dietary alterations and vitamin supplements may assist.

Pathogenesis

Etiology

• A null mutation exists in PDP1, the phosphatase enzyme that activates the pyruvate dehydrogenase complex. Homozygous individuals experience severe exercise intolerance due to a metabolic acidosis.

Predisposing factors

• Dogs with PDP1 deficiency are sensitive to carbohydrate in the diet.

Diagnosis

Treatment

Prevention

Outcomes