ISSN 2398-2969      



Synonym(s): Malignant lymphoma, Lymphosarcoma, LSA


  • Definition: neoplasm arising from lymphoid tissues, in any area of the body. 
  • Most common hemopoietic neoplasm, 7-24% of all canine malignant neoplasms, 83% of all canine hematopoietic malignancies.
  • Forms: multicentric, thymic, alimentary, cutaneous, CNS, hepatic, renal and others. Can be intermediate/high grade or indolent.
  • Signs: depend on form, eg malaise, polydipsia, polyuria, respiratory distress, vomiting, diarrhea, constipation. Multicentric usually presents feeling well and owners notice 'lumps under jaw'.
  • Diagnosis: fine needle aspirate and cytology. Biopsy can be used to better define histologic variants and guide therapy and prognosis. Flow cytometry and PARR can help further with definitive diagnosis. 
  • Treatment: cytotoxic drugs, surgery or radiation therapy can be used to treat localized problematic masses. Radiation therapy can be used for consolidation of tumor following chemotherapy (eg half body radiation therapy). Bone marrow transplantation. Immunotherapy is under development. 
  • Prognosis: poor if no treatment for intermediate/high grade. Fair for indolent lymphomas. 
    Print off the owner factsheet on Canine lymphoma to give to your client.



  • Unknown.
  • Genetic and molecular factors: gain of canine chromosomes 13 and 31, loss of chromosome 14, increase in in duration of first remission and overall survival time in dogs with trisomy 13, germline and somatic genetic mutations as well as altered oncogene/tumor suppressor gene expression have been reported in dogs. 
  • Environmental factors (none definitively proven): herbicides (2,4-D), use of chemicals (paint or solvents), use of pesticides, exposure to strong magnetic fields, exposure to tobacco smoke, proximity to environmental waste. 
  • Impaired immune function is associated with higher risk of developing lymphoma.


  • Malignant proliferation of lymphoid cells arising in any area containing lymphoid tissue → focal or diffuse masses in intestine, skin, thymus or lymph nodes → may progress to extranodal sites, eg liver, spleen, bone marrow.
  • Most common anatomic form, in order of decreasing prevalence: multicentric (80% of dogs with lymphoma), gastrointestinal, mediastinal, cutaneous. Rarer extranodal forms include for example renal, CNS, ocular, hepatosplenic, intravascular.
  • Can be due to malignant proliferation of B, T cell lines, or NK cells.
  • 60-80% are B cell origin, 10-38% T cell, 22% mixed B and T cell, < 5% null cel.
  • T cell tumors have a worse prognosis and poorer survival than B cell tumors.
  • All large cell T cell tumors should be treated as highly malignant and carry a poor prognosis. Small cell T-cell tumors can be very indolent with long term survival.
  • Paraneoplastic effects Neoplasia: paraneoplastic disease, eg hypercalcemia Hypercalcemia: overview (reported in 10-40% of dogs with lymphoma, most common with mediastinal form and T immunophenotype), immune-mediated thrombocytopenia Immune-mediated thrombocytopenia, anemia.


  • Rapidly fatal (4-6 weeks) without treatment for intermediate/high grade. 
  • Months to years of survival for indolent lymphomas (with the exception of nodal marginal zone lymphoma) sometimes even without treatment.


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Further Reading


Refereed papers

  • Recent references from PubMed and VetMedResource.
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  • Hughes K L, Ehrhart E J, Rout E D, Harris L J, Fernandez M (2021) Diffuse Small B-Cell Lymphoma: A High-Grade Malignancy. Vet Pathol PubMed
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  • Morgan E, O'Connell K, Thomson M, Griffin A (2018) Canine T cell lymphoma treated with lomustine, vincristine, procarbazine, and prednisolone chemotherapy in 35 dogs. Vet Comp Oncol 16(4), 622-629 PubMed
  • Saba C F, Vickery K R, Clifford C A, Burgess K E, Phillips B et al (2018) Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses. Vet Comp Oncol16(1), E76-E82 PubMed
  • Sadowski A R, Gardner H L, Borgatti A, Wilson H, Vail D M (2018) Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma. BMC Vet Res 14(1), 250 PubMed.
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Other sources of information

  • Vail D M, Pinkerton M, Young K M (2020) Hematopoietic tumours. In: Withrow & MacEwen’s Small Animal Clinical Oncology. 6th edn. Saunders pp 688-711.
  • Kansas State University modified UW-Madison lymphoma protocol for dogs Lymphoma: chemotherapy protocols.

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