Introduction

• Rare condition reported in a few breeds.
• Consists of marked reduction or absence of cerebral gyri.
• Signs: altered behavior, visual deficits, postural abnormalities and seizures.
• Signs: signs, MRI.
• Treatment: none possible.
• Prognosis: poor.

Pathogenesis

Etiology

• Intrinsic defects in migration of neurons may be caused by metabolic or degenerative alterations during pregnancy.
• Exogenous effects on fetus during gestation.

Predisposing factors

• Intra-uterine hypoxia or perfusion failure.

Pathophysiology

• Marked reduction or absence of cerebral gyri.

• Defect in neuronal migration → marked reduction of cerebral gyri → forebrain dysfunction.

Timecourse

• Insidiously evolving condition with signs detected during the 1st year of life.

Diagnosis

Treatment

Prevention

Outcomes