Kidney: idiopathic cutaneous and renal glomerular vasculopathy

i canis

Contributor(s):

Rosanne Jepson

David Walker

Laura Holm

Synonym(s): CRGV, Alabama rot, Greenetrack disease

Podcast: Kidney: idiopathic cutaneous and renal glomerular vasculopathy

Introduction

Cause: unknown.
Signs: often presents as a cutaneous 'lesion(s)' in an otherwise asymptomatic patient. Patient may or may not subsequently develop clinical signs of acute kidney injury (AKI). AKI may be identified concurrently with skin lesions at initial presentation.
Diagnosis: histopathology reveals a dermal +/- renal vasculopathy. Suspicion is otherwise based upon clinical signs and exclusion of other possible causes of acute kidney injury.
Treatment: aggressive management of acute kidney injury if present. Management of cutaneous lesion(s) as appropriate dependent upon presentation. The etiology of idiopathic cutaneous and renal glomerular vasculopathy is unknown and therefore there is currently no specific therapy.
Prognosis: variable depending upon whether patient presents with cutaneous lesion(s) alone or cutaneous lesions and acute kidney injury. The prognosis in patients that develop acute kidney injury seems to be poor.

Print off the owner factsheet on Alabama rot cutaneous and renal glomerular vasculopathy (CRGV) Alabama rot cutaneous and renal glomerular vasculopathy (CRGV) to give to your client.

General

Unclear as etiology unknown. Histopathological findings in dogs with CRGV are similar to thrombotic microangiopathy (TMA) in people. The main TMAs in people are hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura. Other causes include malignant hypertension, pre-eclampsia, various autoimmune diseases, genetic abnormalities in the immune system, radiation exposure, and drug-induced lesions. The underlying cause of TMA in the dogs with CRGV is unknown.

Most dogs initially present symptomatically well with cutaneous lesions but subsequently develop signs of AKI over a few days (median 4 days; range 1-9 days). Some dogs present with cutaneous lesions and AKI at the same time whilst another subset may present with azotemia Azotemia prior to cutaneous ulceration becoming apparent. Many of the originally reported greyhounds with CRGV had cutaneous lesions only and did not develop AKI.

Unknown. Cases of CRGV in the UK have been identified in many counties. Data collection is ongoing and epidemiological data should become available over time.

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login