Introduction

• Rare - seen in young Great Danes.
• Distribution: UK, Australia, and Canada with most cases to date in the UK.
• Signs: generalized weakness and exercise intolerance.
• Prognosis: poor.

Pathogenesis

Pathophysiology

• Muscle pathology → compromised muscle function → muscle atrophy → generalized weakness, exercise intolerance and stiff gait.
• A specific mutation has not yet been identified.

Diagnosis

Treatment

Outcomes