ISSN 2398-2969      

Hemangiosarcoma

icanis

Synonym(s): Angiosarcoma, hemangioendothelioma, HSA


Introduction

  • Malignant tumor arising from transformed endothelial cells or a pluripotent bone marrow progenitor cells.

Pathogenesis

Pathophysiology

  • Enlarging mass.
  • The blood vessels in the tumor are abnormal and irregular leading to stagnation of blood and clot. The clots prevent blood supply to tumor cells, causing tumor necrosis. This creates small ruptures in the tumor (even in the absence of trauma) with consequent blood loss in the abdomen, pericardial sac, pleural cavity, or subcutaneous space.
  • The abnormal vasculature with associated stagnation of blood predispose to disseminated intravascular coagulation, as well as causing microangiopathic disease.

Timecourse

  • Depends on site.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Masyr A R, Rendahl A K, Winter A L, Borgatti A & Modianon J F (2021) Retrospective evaluation of thrombocytopenia and tumor stage as prognostic indicators in dogs with splenic hemangiosarcoma. JAVMA 258(6), 630-637 PubMed.
  • Moore A S, Rassnick K M & Frimberger A E (2017) Evaluation of clinical and histologic factors associated with survival time in dogs with stage II splenic hemangiosarcoma treated by splenectomy and adjuvant chemotherapy: 30 cases (2011–2014). JAVMA251(5), 559-565 PubMed.
  • Treggiari E, Pedro B, Dukes-McEwan J, Gelzer A R & Blackwood L (2017) A descriptive review of cardiac tumours in dogs and cats. Vet Comp Oncol 15, 273-288 PubMed.
  • Kim J-H, Graef A J, Dickerson E B, Modiano J F (2015) Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives.Vet Sci2, 388-405 PubMed
  • Lana S, U'ren L, Plaza S, Elmslie R, Gustafson D, Morley P & Dow S (2007) Continuous Low-Dose Oral Chemotherapy for Adjuvant Therapy of Splenic Hemangiosarcoma in Dogs. JVIM 21, 764-769 PubMed.
  • Chun R (1999) Feline and canine hemangiosarcoma. Comp Cont Ed 21 (7), 622-652 VetMedResource.
  • Edwards N J (1996) The diagnostic value of pericardial fluid pH determination. JAAHA 32 (1), 63-67 PubMed.
  • Ogilvie G K et al (1996) Surgery and doxorubicin in dogs with hemangiosarcoma. J Vet Intern Med 10 (6), 379-384 PubMed.
  • Ward H et al (1994) Cutaneous hemangiosarcoma in 25 dogs - a retrospective study. J Vet Intern Med 8 (5), 345-348 PubMed.
  • Sorenmo K U, Jeglum K A & Helfand S C (1993) Chemotherapy of canine hemangiosarcoma with doxorubicin and cyclophosphamide. J Vet Intern Med 7 (6), 370-376 PubMed.
  • Hammer A S et al (1991) Hemostatic abnormalities in dogs with hemangiosarcoma. J Vet Intern Med 5 (1), 11-14 PubMed.
  • Hargis A M & Fledman B F (1991) Evaluation of hemostatic defects secondary to vascular tumors in dogs - 11 cases (1983-1988). JAVMA 198 (5), 891-894 PubMed.
  • Aronsohn M (1985) Cardiac hemangiosarcoma in the dog - a review of 38 cases. JAVMA 187 (9), 922-926 PubMed.

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