ISSN 2398-2969      

Cutaneous mucinosis

icanis

Synonym(s): Myxedema


Introduction

  • Uncommon.
  • Cause: various diseases. In some cases may be breed-related or idiopathic.
  • Signs: vesicles due to excessive accumulation of mucin in the dermis.
  • Diagnosis: skin biopsy and use of special staining to identify mucin deposition.
  • Prognosis: good.

Pathogenesis

Etiology

  • Some cases of mucinosis are genetically determined like in the case of Chinese Shar Peis.
  • In other cases mucinosis is secondary to another disease. In systemic lupus Systemic lupus erythematosus the excessive deposition of mucin is caused by an increased production by fibroblast due to a serum factor present in affected individuals.
  • In hypothyroidism the excessive production of mucin is secondary to decreased catabolism of glycosaminoglycans.
  • Mucinosis may be observed also in cases of dermatomyositis and acromegaly Acromegaly.

Pathophysiology

  • Mucin accumulated in the dermis leading to the formation of vesicles. The reason for the excessive accumulation of mucin varies.
  • In some cases mucin accumulates in the oropharynx leading to snoring and snorting.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Zanna G, Fondevila D, Bardagi M, Docampo M J, Bassols A & Ferrer L (2008) Cutaneous mucinosis in shar-pei dogs is due to hyaluronic acid deposition and is associated with high levels of hyaluronic acid in serum. Vet Dermatol 19 (5), 314-318 PubMed.
  • Uetsuka K, Suzuki M, Suehiro M, Ejiri N, Nishimura R, Sasaki N, Nakayama H & Doi K (1999) Generalized dermal dysplasia and perifollicular mucinosis in a dog. Vet Pathol 36 (1), 80-82 PubMed.
  • Welle M, Grimm S, Suter M & von Tscharner C (1999) Mast cell density and subtypes in the skin of Shar Pei dogs with cutaneous mucinosis. Zentralbl Veterinarmed A 46 (5), 309-316 PubMed.
  • von Bomhard D & Kraft W (1998) Idiopathic mucinosis cutis in Chinese Shar pei dogs - epidemiology, clinical features, histopathologic findings and treatment. Tierarztl Prax Ausg K Klientiere Heimtiere 26 (3), 189-96 PubMed.
  • Doliger S, Delverdier M, More J, Longeart L, Regnier A & Magnol J P (1995) Histochemical study of cutaneous mucins in hypothyroid dogs. Vet Pathol 32 (6), 628-634 PubMed.
  • Pandya A G, Sontheimer R D, Cockerell C J, Takashima A & Piepkorn M (1995) Papulonodular mucinosis associated with systemic lupus erythematosus - possible mechanisms of increased glycosaminoglycan accumulation. J Am Acad Dermatol 32 (2 Pt 1), 199-205 PubMed.
  • Dillberger J E, Altman N H (1986) Focal mucinosis in dogs - seven cases and review of cutaneous mucinoses of man and animals. Vet Pathol 23 (2), 132-139 PubMed.

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