ISSN 2398-2969      

Chondrodysplasia

icanis
Contributor(s):

Vetstream Ltd

Synonym(s): Achondroplasia


Introduction

  • Literally means abnormal growth of cartilage and results in disproportionate dwarfism.
  • Cause: genetic cartilage abnormality.
  • Several dog breeds display this as standard conformation, eg Dachshund, Bassett hound.
  • Signs: limb shortening + flared metaphyses, depressed nasal bridge + shortened maxilla → crowding of teeth.
  • Diagnosis: clinical signs.
  • Treatment: none.
  • Prognosis: may be normal, or guarded if congenital defect.

Pathogenesis

Pathophysiology

  • Abnormal interstitial growth of physeal cartilage → generalized shortening of the bones which develop by endochondral ossification:
    • Limbs.
    • Ribs.
    • Vertebral column.
  • Early growth arrest of some bones which make up the cranium → enlarged dome-shaped skull due to continued brain growth.
  • Hypoplasia of base of cranium, ethmoids and turbinates → flattened face → normal sized tongue then protrudes beyond jaw.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

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