ISSN 2398-2969      

Multi-drug resistance gene (MDR1) in dogs

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Multi-drug resistance gene (MDR1) in dogs

The problem associated with the Multi-drug resistance gene (MDR1) mutation first became apparent when it was noticed that ivermectin administration lead to severe neurological signs, seizures and death in Rough Collies. The gene defect affects many herding breeds and means that these breeds can be particularly sensitive to certain drugs.

What is the MDR1 gene?

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Why is the MDR1 gene important?

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Which breeds can be affected?

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How would I know if my dog was affected?

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Is there a test for MDR1 mutation?

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What should I do if my pet has MDR1 mutated gene?

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Should I breed from my dog?

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