ISSN 2398-2993      

Benzylpenicillin

obovis
Contributor(s):

Eilidh Thomson

Andrea Tarr

Synonym(s): Penicillin G procaine, Procaine benzylpenicillin


Introduction

Name

  • Penicillin G procaine
  • Benzylpenicillin is available as three different salts:
    • Sodium benzylpenicillin
    • Procaine benzylpenicillin
    • Benzathine benzylpenicillin 
  • This article focuses on the procaine salt, procaine benzlypenicillin.
    • At the time of publishing, only procaine benzylpenicillin was licensed for use in the UK.

Class of drug

  • Beta lactam antibiotic.

Description

Chemical name

  • N,N'-dibenzylethane-1,2-diamine;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Molecular formula

  • C16H18N2O4S.C13H20N2O2.H2O. 

Molecular weight

  • 588.72.

Physical properties

  • White suspension for injection.
  • Intramammary formulations available.

Storage requirements

  • Varies between products:
    • Some store in fridge between 2°C/35.6°F and 8°C/46.4°F.
    • Some store below 25°C/77°F.

Uses

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Indications

  • To treat infections caused by bacteria sensitive to penicillin.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Try not to use with bacteriostatic antibiotics.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • D Canzani & F Aldeek (2017) Penicillin G’s function, metabolites, allergy and resistance. J Nutri Human Health 1 (1), 28-40
  • A Omidi (2009) Anaphylactic reaction in a cow due to parenteral administration of penicillin-streptomycin. Can Vet J 50 (7), 741-744 PubMed.

Other sources of information

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
  • Veterinary Medicines Directorate (VMD) Product Information Database. Website: www.vmd.defra.gov.uk.

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