Blood biochemistry: gammaglutamyl transferase

• Gammaglutamyl transferase (GGT) is a membrane-associated enzyme.
• In the rabbit GGT is found in the liver and in the kidney
• Liver GGT is found primarily in the epithelium of the bile ducts.
• The hepatobiliary system is therefore the primary source of serum GGT and is more diagnostic for hepatobiliary disease than for hepatocellular damage.
• In the rabbit, GGT is also located in renal epithelium and in cases of renal damage, urine GGT may be increased in addition to plasma concentrations.

Uses

In combination

• Hepatobiliary disease.
• Renal damage (increase in urine GGT levels as well).
• In other species it can be associated with cholestatic disorders, liver damage, biliary obstruction or damage (neoplasia, inflammation, cholelithiasis, intrahepatic or extrahepatic cholestasis or other biliary compromise).