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Itraconazole

ISSN 2398-2969


Synonym(s): Sporanox®, Itrafungol™, Fungitraxx®

Introduction

Name

  • Itraconazole.

Class of drug

  • Triazole antifungal.

Description

Chemical name

  • 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one.

Molecular formula

  • C35H38Cl2N8O4.

Molecular weight

  • 705.6 g/mol.

Physical properties

  • Lipophilic.

Storage requirements

  • Store capsules at room temperature protected from light and moisture.
  • Store oral solution at room temperature (20-25°C/68-77°F).
  • Oral suspension stored in refrigerator for up to one month.

Uses

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Administration

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Pharmacokinetics

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Precautions

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Withdrawal Periods

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Fehr M (2015) Zoonotic potential of dermatophytosis in small mammals. J Exot Pet Med 24 (3), 308-316 SciDirect.
  • Keller K A (2011) Therapeutic review: itraconazole. J Exotic Pet Med 20 (2), 156-160 SciDirect.
  • Patterson T F, Fothergill A W & Rinalsi M G (1993) Efficacy of itraconazole solution in a rabbit model of invasive aspergillosis. Antimicrob Agents Chemother 37 (11), 2307-2310 PubMed.

Other sources of information

  • National Center for Biotechnology Information (2022) PubChem Compound Summary for CID 55283, Itraconazole. Website: https://pubchem.ncbi.nlm.nih.gov.
  • Carpenter J W (2021) Appendix: Formulary. In: Ferrets, Rabbits and Rodents Clinical Medicine and Surgery. 4th edn. Eds: Quesenberry K E, Orcutt C J, Mans C & Carpenter J W. Elsevier, USA. pp 620-630.
  • Hedley J (2020) Ed BSAVA Small Animal Formulary. Exotic Pets. 10th edn. BSAVA, UK.