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Tacrolimus
Synonym(s): FK506
Introduction
Name
- Tacrolimus.
Class of drug
- Macrolide lactone antibiotic with potent immunosuppressive activity.
- Produced by Streptomyces tsukubaensis.
Description
Molecular formula
- C44H69NO12.H2O.
Molecular weight
- 822 kilodaltons.
Physical properties
- Lipid soluble.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Adverse reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
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Olivry T, Foster A P, Mueller R S et al (2010) Interventions for atopic dermatitis in dogs: a systematic review of randomized controlled trials. Vet Dermatol 21 (1), 4-22 PubMed.
- Chung T H, Ryu M H, Kim D Y et al (2009) Topical tacrolimus (FK506) for the treatment of feline idiopathic facial dermatitis. Aust Vet J 87 (10), 417-420 PubMed.
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Kano R, Okabayashi K, Nakamura Y et al (2006) Systemic Treatment of Sterile Panniculitis with Tacolimus and Prednisolone in Dogs. J Vet Med Sci 68(1), 95-96 PubMed.
- Marsella R, Nicklin C F, Saglio S et al (2004) Investigation on the efficacy and safety of 0.1% tacrolimus ointment (Protopic®) in canine atopic dermatitis: a randomized, double blinded, placebo controlled, cross over study. Vet Dermatol 15 (5), 294-303 PubMed.
- Marsella R, Nicklin C F, Saglio S et al (2004) Investigation on the effects of topical therapy with 0.1% tacrolimus ointment (Protopic®) on intradermal skin test reactivity in atopic dogs. Vet Dermatol 15 (4), 218-224 PubMed.
- Marsella R & Nicklin C F (2002) Investigation on the use of 0.3% tacrolimus lotion for canine atopic dermatitis: a pilot study. Vet Dermatol 13 (4), 203-210 PubMed.
- Marsella, R & Olivry T (2001) The ACVD task force on canine atopic dermatitis (XXII): nonsteroidal anti-inflammatory pharmacotherapy. Vet Immunol Immunopathol 81 (33-34), 331-345 Review PubMed.
- Paller A, Eichenfield L F, Leung D Y et al (2001) A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients. J Am Acad Dermatol 44, S47-57 PubMed.
- Misseghers B S, Binnington A G & Mathews K A (2000) Clinical observations of the treatment of canine perianal fistulas with topical tacrolimus in 10 dogs. Can Vet J 41 (8), 623-627 PubMed.
- Plosker G L & Foster G H (2000) Tacrolimus, a further update of its pharmacology and therapeutic use in the management of organ transplantation. Drugs 59 (2), 323-389 PubMed.
- Vaden S L (1997) Cyclosporine and tacrolimus. Semin Vet Med & Surg (Small Anim) 12 (3), 161-166 Review PubMed.
- Kelly P A, Burckart G J & Venkataramanan R (1995) Tacrolimus: a new immunosuppressive agent. Am J Health-Syst Pharm 52 (14), 1521-1535 PubMed.
- Thomson A W, Bonham C A & Zeeva A (1995) Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit 17 (6), 584-591 PubMed.
- Fukuse T, Hirai T, Yokomise H et al (1993) Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. J Heart Lung Transplant 12 (6 pt 1), 941-947 PubMed.
Other sources of information
- Hovda L & Brutlag A (2016) Blackwell’s Five-Minute Veterinary Consult Clinical Companion: Small Animal Toxicology. John Wiley & Sons.